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The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues
a ligand of ubiquitin E3 ligase cereblon (CRBN)
InChi: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29
Chemical Name: 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)(2
CAS Number: 849214-04-6
AP-18 Size:Contact [email protected] for quotation The antiangiogenic agent ZD4190 preventsAP 18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 M Cinnamaldehyde with an IC50 of 3. 1 M and 4. 5 M for human and mouse TRPA1, respectively. AP 18 reverses complete Freund's adjuvant (CFA) induced mechanical hyperalgesia in mice. AP 18 attenuated 30 M AITC induced Yo Pro uptake in a concentration dependent manner, with an IC50 of 10. 3 M. Product information CAS Number: 55224 94 7 Molecular Weight: 209. 67 Formula:
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